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Design Eighty-six different clinical parameters were collected using an electronic clinical research form designed by the Hungarian Pancreatic Study Group.

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Patients adult patients diagnosed with AP were prospectively enrolled from 17 Hungarian centres over a two-year period from 1 January Main Results With respect to aetiology, biliary and alcoholic pancreatitis represented the two most common forms of AP. The prevalence of biliary AP was higher in women, whereas alcoholic AP was more common in men. Hyperlipidaemia was a risk factor for severity, lack of serum enzyme elevation posed a risk for severe AP, and lack of abdominal pain at admission demonstrated a risk for mortality.

Abdominal tenderness developed in all the patients with severe AP, while lack of abdominal tenderness was a favourable sign for mortality.

Importantly, lung injury at admission was associated with mortality. With regard to laboratory parameters, white blood cell count and CRP were the two most sensitive indicators for severe AP. The most common local complication was peripancreatic fluid, whereas the most common distant organ failure in severe AP was lung injury.

Conclusions Analysis of a large, nationwide, prospective cohort of AP cases allowed for the identification of important determinants of severity and mortality. Evidence-based guidelines should be observed rigorously to improve outcomes in AP.

This is an open access article distributed under the terms of the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability: All relevant data are within the paper and its Supporting Information files.

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The authors have declared that no competing interests exist.

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Introduction Acute pancreatitis AP is a serious disease with high mortality [ 1 ]. Published studies on the clinical characteristics of AP [ 45 ] have mostly been based on retrospective cohorts or prospectively collected data from — cases [ 45 ].

Large, nationwide, alcohol and blood pressure reddit collected cohorts are needed. Therefore, dissemination and validation of newly described guidelines are important.

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All the participants provided written informed consent to participate in this study. The ethics committee have carefully checked and approved the consent procedure. To achieve our aims, we developed a uniform prospective electronic data registry www.

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For this HPSG study cohort, patients in Hungary were prospectively enrolled for two years between 1 January and 1 January Centre distribution is indicated in S1 Fig. Two of the following alterations were confirmed in each patient: abdominal pain clinical symptompancreatic enzyme elevation at least three times above the upper limit and morphological changes imaging lonc és magas vérnyomás. Eighty-six different parameters were collected see S2 Fig.

The missing data were either not measured e. Only four of the collected parameters were not analysed due to a high amount of missing data.

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Please note that some of the presented data are difficult to measure for example alcohol consumption, pain, type of pain, tenderness etc. For descriptive statistics, the number of patients, mean, standard deviation SDminimum, median and maximum values were calculated for continuous variables, and the case number and percentage were computed for categorical values.

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For inferential statistics, the following statistical tests were used for determining statistical significance of differences between groups. To compare two groups of independent samples, the t-test was applied for normally distributed data and the Mann—Whitney U test for non-normal data.

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To compare more than two groups, one-way ANOVA with the Bonferroni adjustment method was used for normally distributed data with homogenous group-wise standard deviation; Brown-Forsythe Levene-type test was applied to test of variance homogeneity; the Welch test followed by the Games—Howell post hoc test for normally distributed data with heterogeneous group-wise standard deviation; and the Kruskal—Wallis test followed by the Bonferroni p value adjustment method for non-normal data.

The association between categorical variables was examined with the Chi-square test and Fisher's exact test.

Szakmai gyakorlatot szerez a képzési idő alatt Gyakorlatias tudást sajátít el, biztos problémamegoldó készségre tesz szert Munkavállalói kompetenciákkal gazdagodik A legjobban teljesítő hallgatók közül új munkavállalókat választhat A hosszabb gyakorlati idő alatt biztosabbá válik az ismeretek átadása Potenciális munkavállalóit testreszabott módon képezheti szakmaspecifikus felkészítés, már az oktatási időszakban megvalósul Szakmai támogatóként, piaci szereplőként bekapcsolódik a felsőoktatás számára fontos képzési programjába Miért jó a felsőoktatásnak? Az új típusú képzés új hallgatói jelentkezéseket eredményez Minősített gyakorlati helyeket tud biztosítani hallgatói számára Gyakorló szakemberek bevonásával tudja megvalósítani a képzési programot Élő, ipari kapcsolatokra tesz szert Mit jelent a dualitás a képzésben, munkavégzésben? Ebből évente átlagosan 26 hetet vesz igénybe az elméleti és 22 hetet a gyakorlati képzésre fordított idő. Az informatikai képzésre vonatkozóan a mi rendszerünkben az első 2 évben kevesebb gyakorlatod lesz 18 hét éventemelyet az elméleti oktatást követő időszakban kell teljesítened. A cég a hallgatóval hallgatói munkaszerződést köt, melyben a gyakorlati munkavégzés, munkakörülmények mellett rögzítésre kerül a járandóság és a szabadság.

For categorical variables the multiple comparison between groups were not applied. The relevant statistical tests are also described in the legends to the figures.

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Statistical analyses were prepared by SPSS With regard to the age distribution of the cases, AP incidence in the males increased between 33 and káliumsó magas vérnyomás esetén years and remained high until 68 years, after which it sharply declined. In the females, the highest incidence was alcohol and blood pressure reddit 53 and 78 years Fig 1B. The majority The incidence of severe AP demonstrated an age-dependent rise between 23 and 58 years.

In contrast, the frequency of mild or moderate AP did not show a similar age distribution Fig 1Dsuggesting that age may be a risk factor for disease severity.